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  • TERPENE

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Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011 Aug;163(7):1344-64.

Rufino, Ana Teresa et al. “Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis.” European journal of pharmacology vol. 750 (2015): 141-50. 

do Vale, T Gurgel et al. “Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 9,8 (2002): 709-14.

Mizrahi, Boaz et al. “Citrus oil and MgCl2 as antibacterial and anti-inflammatory agents.” Journal of periodontology vol. 77,6 (2006): 963-8.

Lima, Naiana G P B et al. “Anxiolytic-like activity and GC-MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants.” Pharmacology, biochemistry, and behavior vol. 103,3 (2013): 450-4. 

Sun, Jidong. “D-Limonene: safety and clinical applications.” Alternative medicine review : a journal of clinical therapeutic vol. 12,3 (2007): 259-64.

Komori, T et al. “Effects of citrus fragrance on immune function and depressive states.” Neuroimmunomodulation vol. 2,3 (1995): 174-80. 

Vigushin, D M et al. “Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee.” Cancer chemotherapy and pharmacology vol. 42,2 (1998): 111-7. 

Miller, Jessica A et al. “Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.” Cancer prevention research (Philadelphia, Pa.) vol. 6,6 (2013): 577-84. 

Kim, Dae-Seung et al. “Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages.” The American journal of Chinese medicine vol. 43,4 (2015): 731-42. 

Rohr, Annette C et al. “Upper airway and pulmonary effects of oxidation products of (+)-alpha-pinene, d-limonene, and isoprene in BALB/c mice.” Inhalation toxicology vol. 14,7 (2002): 663-84.

Yang, Zhiwei et al. “Comparative anti-infectious bronchitis virus (IBV) activity of (-)-pinene: effect on nucleocapsid (N) protein.” Molecules (Basel, Switzerland) vol. 16,2 1044-54. 25 Jan. 2011.

Maurya, A. K. et al., (2014). α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Current pharmaceutical biotechnology, 15(2), 173–181.

Anthony J. De Lucca et al., (2011) Fungicidal and Bactericidal Properties of Bisabolol and Dragosantol, Journal of Essential Oil Research, 23:3, 47-54,

Sundstrup, Emil et al. “Acute effect of topical menthol on chronic pain in slaughterhouse workers with carpal tunnel syndrome: triple-blind, randomized placebo-controlled trial.” Rehabilitation research and practice vol. 2014 (2014): 310913. 

Pergolizzi, J V Jr et al. “The role and mechanism of action of menthol in topical analgesic products.” Journal of clinical pharmacy and therapeutics vol. 43,3 (2018): 313-319. 

Zaia, Mauricio G et al. “Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection.” Frontiers in pharmacology vol. 7 170. 17 Jun. 2016.

Linck, V M et al. “Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 17,8-9 (2010): 679-83. 

Peana, Alessandra T et al. “Involvement of adenosine A1 and A2A receptors in (-)-linalool-induced antinociception.” Life sciences vol. 78,21 (2006): 2471-4. 

Peana, A T et al. “Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 9,8 (2002): 721-6. 

Sabogal-Guáqueta, Angélica Maria et al. “Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice.” Neuropharmacology vol. 102 (2016): 111-20.

Fernandes, Elizabeth S et al. “Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.” European journal of pharmacology vol. 569,3 (2007): 228-36. 

Pichette, André et al. “Composition and antibacterial activity of Abies balsamea essential oil.” Phytotherapy research : PTR vol. 20,5 (2006): 371-3. 

do Vale, T Gurgel et al. “Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 9,8 (2002): 709-14.

Legault, Jean et al. “Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action.” Planta medica vol. 69,5 (2003): 402-7.

Klauke, A-L et al. “The cannabinoid CB₂ receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain.” European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol. 24,4 (2014): 608-20. 

Horváth, Béla et al. “β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner.” Free radical biology & medicine vol. 52,8 (2012): 1325-33. 

Bahi, Amine et al. “β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.” Physiology & behavior vol. 135 (2014): 119-24. 

Khan A et al. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease. Neurochem Res. 2014 Feb;39(2):344-52. 

Chehregani A, Atri M, Yousefi S, Albooyeh Z, Mohsenzadeh F. Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity. Pharm Biol. 2013 Feb;51(2):246-52.